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Pediatrics the pharmacokinetic profile of toprol-xl was studied in 120 pediatric hypertensive patients 6-17 years of age receiving doses ranging from 12.

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, ether have a condition known as right ventricular failure caused by excessive blood pressure in the lungs have a condition known as sick sinus syndrome have a slow heartbeat caused by heart rhythm problems have asthma or other obstructive respiratory diseases for the intravenous form of metoprolol only have cardiogenic shock have overt heart failure have serious heart block have severe circulatory disorders have had a heart attack accompanied by a heart rate less than 45 beats per minute significant heart block very low blood pressure moderate to severe cardiac failure.

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Metoprolol crosses the blood-brain barrier and has been reported in the csf in a concentration 78 of the simultaneous plasma concentration.

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At the end of the study, the mean daily dose of toprol-xl was 159 zithromax 250 mg mg.

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If angina markedly worsens or acute coronary ischemia develops, promptly reinstate toprol-xl, and take measures appropriate for the management of unstable angina.

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by reducing the heart rate and the force of muscle contraction, metoprolol reduces heart muscle oxygen demand.